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KMID : 0882420160900010059
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Korean Journal of Medicine
2016 Volume.90 No. 1 p.59 ~ p.62
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Incidentally Found Chronic Neutrophilic Leukemia in a Patient with Rectal Cancer
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김석형:Kim Seok-Hyung
박해열:Park Hae-Yeul/황창혁:Hwang Chang-Hyeok/정영학:Jung Young-Hak/이민주:Lee Min-Joo/최성은:Choi Sung-Eun/김유리:Kim Yu-Ri
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Abstract
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Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy. Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer.
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KEYWORD
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Leukemia, Neutrophilic, Chronic, Leukemoid reaction, Leukocytosis
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